Journal: Frontiers in Pharmacology

Article Title: Identification, screening, and comprehensive evaluation of novel thrombin inhibitory peptides from the hirudo produced using pepsin

doi: 10.3389/fphar.2024.1460053

Figure Lengend Snippet: In vitro anticoagulant activity of different P1 concentrations (APTT; TT; PT). Values are represented as means ± SD (n = 3). Compared with the blank group, *p < 0.05; **p < 0.01; **** p < 0.0001.

Article Snippet: Recombinant hirudin was purchased from Tianjin Xiensi Biological Technology Co., Ltd. (Tianjin, China); The extract of hirudo was provided by Beijing Kang’er Fu pharmaceutical Co., Ltd.; Pepsin, thrombin, chromogenic substrate S-2238 and adenosine diphosphate (ADP) were purchased from Shanghai Yuanye Bio-Technology Co., Ltd. (Shanghai, China); Prothrombin Time (PT) reagent, Activated partial thromboplastin time (APTT) reagent, calcium chloride, and Thrombin Time (TT) reagent were purchased from Stago Co., Ltd.; The synthetic peptides were obtained from Shanghai Top-Peptide Biotechnology Co., Ltd (Shanghai, China).

Techniques: In Vitro, Activity Assay

Journal: PLoS ONE

Article Title: Statistical Methods Used to Test for Agreement of Medical Instruments Measuring Continuous Variables in Method Comparison Studies: A Systematic Review

doi: 10.1371/journal.pone.0037908

Figure Lengend Snippet: Examples of inappropriate applications and interpretations of statistical analyses to assess agreement found in this review.

Article Snippet: Ten 2007 n = 355 , To compare four different commercial activated partial thromboplastin time (aPTT) reagents to detect shortened aPTT. , Correlation coefficients among the four methods ranged from 0.51 to 0.83 (all P values <0.001). Acceptable agreement between the different commercial reagents was found with respect to detection of short aPTT. Good agreement were found between Instrumentation Laboratory and bioMerieux reagents (r = 0.74–0.83).

Techniques: In Vivo